Don't under-estimate Regina - she is clearly her mother's daughter, in some ways. I can see Regina either poisoning Snow against her father and/or killing Leopold in a way the keeps the blame off of her. (I mean, imagine if everything with Glass happened the same - but she spun it that he was obsessed but she never reciprocated, and Glass still killed Leopold to get him 'out of the way.' Then, public execution of Glass, all the witnesses are gone, and Regina plays the grief-stricken queen to the hilt.)
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